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54gene Completes Initial Phase of the Landmark Nigerian 100K Genome Project

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54gene, the health technology company advancing African genomics research for improved global health outcomes, has through its non-profit initiative, the African Centre for Translational Genetics (ACTG), completed its first consortium-led publication on over 100,000 Nigerians as commissioned in 2020 at its launch.

The Non-Communicable Diseases Genetic Heritage Study (NCD-GHS) consortium has published a paper in the esteemed journal, Nature Genetics, entitled “Promoting the Genomic Revolution in Africa through the Nigerian 100k Genome Project”.

Through 54gene’s ACTG, the consortium operates as a unique public-private partnership involving leading African scientists guided by a team of global genomic leaders as the Scientific Advisory Board to achieve the mission of the ACTG.

The consortium, which is made up of scientists from 54gene, the Nigerian Institute of Medical Research, and the Center for Genomics Research and Innovation at the National Biotechnology Development Agency as well as researchers from multiple academic institutions in Nigeria and London School of Hygiene and Tropical Medicine, is built on a shared vision of positioning African populations to benefit from advances in genomic science.

According to the paper, as of January 2019, approximately 3% of genomic data being used for genome wide association studies (GWAS) came from people of African descent, with this statistic dropping to 1.1% in 2021.

The paper details efforts in building an important resource that could significantly enable African populations to benefit from the global efforts at achieving precision medicine for various diseases.

This has been achieved through the production of a comprehensive catalog of human genetic variation, examining the characteristics of non-communicable diseases (NCDs) in 100,000 adults in Nigeria seeking to understand the genetic basis of the highly prevalent illnesses such as cancers, diabetes, Alzheimer’s, chronic kidney and sickle cell disease, among others.

Non-communicable diseases (NCDs) kill more than 41 million people every year, accounting for 71% of all deaths globally. The prevalence of NCDs is projected to become higher than that of infectious diseases in Africa by 2030.

The study spans the breadth of the Nigerian population with data gathered from the 6 geopolitical zones in the country and sampling from the majority of the more than200 ethnolinguistic groups, with ethically consulted participants being recruited falling under two categories: disease cases recruited from disease specialist clinics, and community cases which are individuals with initially unknown diseases recruited from communities through household surveys.

Dr. Abasi Ene-Obong, 54gene Founder and CEO, said, “Along with our partners, we are proud to be leading the new frontier of African genomics. Precision medicine goes against the one-size-fits-all approach to disease treatment as it is more inclusive, with people treated on their unique genetic makeup.

With more than 200 ethnic groups and 500 different languages, Nigeria has one of the most diverse ethnolinguistic concentrations in the world. This pioneering study from the Nigerian population provides an excellent window into the representation of diversity across Africa.

With recruitment nearly complete and the commencement of data generation and bioinformatics analysis, we are excited at how this study makes the promise of precision medicine more attainable to Nigerians, Africans and the global population.”

Dr. Segun Fatumo, co-lead NCD-GHS and the first author of the landmark paper said, “I am so proud of what NCD-GHS has achieved in only about two years. In our own eyes, 100K genomes of Africa are emerging from more than 300 diverse ethnic groups in Nigeria.

“The current lack of genomic diversity has resulted in significant missed scientific and medical opportunities, but NCD-GHS strategic vision to drive new large-scale studies with rich African genome datasets would  help fill some gaps. I am deeply honoured to be a co-lead of this initiative.

“The NCD-GHS’s public-private partnership with 54gene pioneers a model to increase diversity in genomic studies, including capacity building and plan to develop more genomic leaders in Africa.”

Speaking on the publication of the research paper, Colm O’Dushlaine, Vice President, Genomics and Data Science at 54gene, said, “The 100k project supports 54gene’s core mission to equalize precision medicine, by building rich genomic datasets that will be used to generate powerful insights for the benefit of African, and other global populations.

“African populations are among the most diverse in the world. In the context of genome-wide association scans, more variation – more shots on goal – can help to provide new insights into the etiology of disease and drive novel therapeutic target discovery.

“The broader strategic objectives of the NCD-GHS are far-reaching. They include a focus on the creation of genomics leaders in Africa, efforts to increase the number of skilled African genomics scientists to help drive new studies and discoveries, initiatives that drive progressive health policy and practice, and the promotion of discourse and thought leadership on ethical, legal and social issues in genomics research and precision medicine. All of these are central to 54gene’s mission and values.”

Aminu Yakubu, VP Research Governance and Ethics, said, “Building on the legacy of the H3Africa project, the capacity building objective of the NCD-GHS in the 100K Genome Project is a strategic undertaking that would catalyse the future we envisage – of Africans with the skillset and knowledge, able to lead genomic insights generation and development to address health challenges faced by Africans over the long haul.

“It is a people-facing impact creation initiative that puts the social value of the work we do at the center, facilitated through the African Center for Translational Genetics. The focus of one of the NCD-GHS agendas on governance and ethics was deliberate to ensure that we are aligned with existing country-specific and international best practices.

“Our commitment to also support academic thought leadership on ethics and governance issues in genomics research would allow us to evolve as we learn of better ways to protect the welfare of research participants and ensure fairness in research collaborations.”


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Nigeria to Receive Leprosy Drugs after Year-Long Delay

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World Health Organization (WHO) has said  it will send leprosy drugs to Nigeria this weekend after resolving testing hold-ups that led to a year-long delay in thousands of patients, including children, getting the medicine they need to prevent disability.

Nigeria to Receive Leprosy Drugs after Year-Long Delay

Africa’s most populous nation, Nigeria reports over 1,000 cases of leprosy yearly, a disease caused by a bacterium, Mycobacterium leprae, and mainly affecting the skin, peripheral nerves, and eyes.

It is curable with multi-drug therapy, but without treatment, the disease progresses and causes disfiguring sores and disabilities like blindness and paralysis. Patients also face significant stigma.

But Nigeria ran out of stock of the multi-drug therapy in early 2024 as a bureaucratic delay in supplies and new domestic testing regulations on imported medicines held up the drugs in India, where one of the components is made.

The delay, which caused significant suffering in Nigeria, is just one example of the vulnerability of a global system that has seen stockouts in countries including India, Brazil and Indonesia in recent years, the U.N. special rapporteur for leprosy told Reuters.

A WHO spokesperson told Reuters that Nigeria had run out of leprosy medications, and the U.N. health agency, which organises shipments of the drug, had asked for a one-time waiver on the new testing policy. In January that waiver was granted.

“A dispatch of leprosy drugs from India has been confirmed for 8 March, with arrival in Nigeria on 9 March,” the spokesperson said by email.

Awwal Musa, one of the patients, said her health had deteriorated in the past year since her treatment stopped. All her fingers were clawed and her legs discharged pus.

“Before last year, my wounds were getting healed but now they are getting worse. The pain is worse,” she told Reuters during a visit to the health facility.

 

 


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NITDA, NUC Strengthen Partnership to Implement Digital Literacy and Skills Curriculum

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The National Information Technology Development Agency (NITDA) and the National Universities Commission (NUC) have renewed their commitment to implementing the Digital Literacy and Skills Curriculum across all Nigerian universities.

This was announced during the Director General of NITDA, Kashifu Inuwa and his management team visit to the National Universities Commission (NUC), where they engaged with the newly appointed Executive Secretary, Professor Abdullahi Yusufu Ribadu.

The visit provided an opportunity to reignite the implementation of this ambitious initiative, which was agreed upon during the initial visit in December 2024, and to reinforce the commitment of both organisations toward integrating digital literacy into Nigeria’s higher learning institutions.

During the meeting, Inuwa emphasised that human capital development is at the heart of national progress, and that there is need to reform Nigeria’s education system by reviewing university curricula to incorporate digital skills and emerging technologies such as Artificial Intelligence (AI), Blockchain, Internet of Things ((IoT) Cloud computing, and Cybersecurity.

He said, “With the rapid advancement of technology, digital skills have become a necessity for success in today’s workforce. This collaboration is a strategic move to equip Nigerian students with the competencies needed to thrive in a technology-driven world, enhancing job creation, entrepreneurship, and overall economic resilience.

“We must review the school curriculum to embed digital literacy and skills, ensuring that our graduates are not just degree holders but are equipped with the necessary competencies to thrive in a technology-driven world. Education reform is critical, and implementing this curriculum across all universities will be a game-changer in our nation’s development,” Inuwa stated.

This partnership aligns and NITDA’s Strategic Roadmap and Action Plan (SRAP 2.0), underscoring the critical role of digital literacy in preparing the nation’s youth for the future.

He further stressed the initiative aligns with President Bola Ahmed Tinubu’s administration priorities of reforming the economy to deliver sustained inclusive growth, and accelerating diversification through industrialization, digitization, creative arts, manufacturing and innovation.

Inuwa added that empowering young Nigerians with digital knowledge would drive economic transformation by creating a workforce that is innovative, entrepreneurial, and ready to meet the challenges of the modern economy.

Professor Ribadu, in his response, reaffirmed NUC’s unwavering commitment to the full implementation of the Digital Literacy and Skills Curriculum, emphasisng the Commission’s dedication to fostering innovation and digital transformation within the higher education sector.

He commended NITDA for its leadership in driving Nigeria’s digital agenda and assured that NUC would work closely with the agency to ensure seamless integration of the initiative into university curricula nationwide.

He acknowledged that digital education is central to Nigeria’s vision of becoming a leading knowledge-based economy and pledged to facilitate necessary policy adjustments to support this goal.

The collaboration between NITDA and NUC will involve a structured implementation plan, capacity-building programmes for educators, and the deployment of digital infrastructure to facilitate seamless adoption. Universities will also be encouraged to incorporate emerging technologies into their curricula, ensuring students are equipped with skills that align with global industry standards.

The initiative is also expected to bridge the digital divide, ensuring that students from all backgrounds, including those in rural and underserved areas, have access to quality digital education.

As technology continues to reshape industries and societies worldwide, Nigeria’s investment in digital literacy will serve as a catalyst for long-term socio-economic transformation.

With strong commitment from both NITDA and NUC, the implementation of the Digital Literacy and Skills Curriculum will mark a new era in Nigeria’s education sector, fostering a generation of tech-savvy graduates who are well-prepared to drive the nation’s digital economy forward.


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FG Lists Simon Ekpa, 16 Others as Terrorism Financiers, Freezes Accounts

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Nigeria Sanctions Committee (NSC) has designated Simon Ekpa, 16 other persons and two entities, for their alleged involvement in supporting terrorist activities and terrorism financing.

FG Lists Simon Ekpa, 16 Others as Terrorism Financiers, Freezes Accounts

Simon Ekpa

The committee further directed financial institutions to freeze their assets and report any transactions related to the individuals and entities to the Sanctions Committee and the Nigerian Financial Intelligence Unit (NFIU).

Those named on the list include Simon Ekpa, Godstime Promise Iyare, Francis Mmaduabuchi, John Onwumere, Chikwuka Eze, Edwin Chukwuedo, Chinwendu Owoh, Ginika Orji, Awo Uchechukwu, and Mercy Ebere Ifeoma Ali.

Others are Ohagwu Juliana, Eze Okpoto, Nwaobi Chimezie, Ogomu Kewe, Igwe Ka Ala Enterprises, Seficuvi Global Company, and Lakurawa Group.

According to a document obtained from the committee on Thursday, the list was approved by the President upon the recommendation of the Attorney General of the Federation.

“The Nigeria Sanctions Committee held a meeting on March 6, 2024, where specific individuals and entities were recommended for designation following their involvement with terrorism financing.

“The Attorney General of the Federation, with the approval of the President, has thereupon designated the following individuals and entities to be listed on the Nigeria Sanctions List.

“In accordance with Section 54 of the Terrorism (Prevention and Prohibition) Act, 2022, you are required to:

“(a) Immediately identify and freeze, without prior notice, all funds, assets, and any other economic resources belonging to the designated persons in your possession and report the same to the Sanctions Committee.

“(b) Report to the Sanctions Committee any assets frozen or actions taken in compliance with the prohibition requirements.

“(c) Immediately file a Suspicious Transactions Report (STR) to the NFIU for further analysis of the financial activities of such individuals or entities.

(d) Report as an STR to the NFIU all cases of name matching in financial transactions prior to or after receipt of this list.”

The committee ordered the immediate freezing of bank accounts and financial instruments associated with the listed individuals and entities across multiple banks, payment platforms, and financial institutions.

“Freezing measures should be extended to all accounts associated with the designated subjects. For designated entities, this should include accounts linked to their signatories and directors to ensure comprehensive enforcement of the sanctions regime,” the document added.

The committee also stated that financial institutions and relevant stakeholders have been instructed to enforce the sanctions and submit compliance reports to the Nigeria Sanctions Committee via [email protected] and

[email protected].

 

See the full list of the frozen accounts below

 

  1. Simon Ekpa Njoku 21-03-1985 Guaranty Trust Bank 0118835791, 0115442299, 0115442275
  2. Godstime Promise Iyare 20-05-1996 Access Bank 0060032439, 1187008630, 1448136683. UBA 2212655102. Moniepoint 8197394552. Kuda 2007096158. Promicool Venture- Moniepoint 8197394576.
  3. Francis Chukwuedo Mmaduabuchi 27-09-1987 Eco Bank 3941072599, Fidelity 6239280146, Opay 8037688095, Moniepoint 8196060258, 8196028438, 8196028452,5380383959, 5612325508,4730823866, 8037688095
  4. John Anayo Onwumere 05-03-1987 Sterling 0026224269, Zenith 4230646454
  5. Chikwuka Godwin Eze 05-05-1975 First Bank 3031299977, Access Bank 0110709618, 0108595489, 1132518632
  6. Edwin Augustine Chukwuedo 27-05-1983 Union 0010808495, 0110232286, 0069247850, Eco Bank 2321194539, Opay 8169916076, Moniepoint 6786290317, 6786290300
  7. Chinwendu Joy Owoh 10-02-1982 First Bank 3125731837, GTB 0115848475, Moniepoint 6474876289, Union 0014660761
  8. Ginika Jane Orji 05-10-1995 Blueridge 8039231985, Opay 7059681248, 8106940744
  9. Awo Uchechukwu 11-12-1978 First Bank 3060144916
  10. Mercy Ebere Ifeoma Ali 07-07-1998 Access 1612608952, FCMB 6594319019, First Bank 3147574474
  11. Ohagwu Nneka Juliana 15-08-1985 UBA 2147559148
  12. Eze Chibuike Okpoto 12-01-1989 Access 0071127599, 1138098116, FCMB 3723955016, GT Bank 0123014963
  13. Nwaobi Henry Chimezie 12-06-1991 Access 1113046148, 1113046148, UBA 2115584448, 2117752704, First Bank 3067985749, Moniepoint 8276850931,
  14. Ogomu Peace Kewe 27-06-1997 Access 1840168323, UBA 2096777826, First Bank 3124937333, 2041450556, (USD) 3180578127, Zenith 2547460190, Opay 9069071154, Kuda 2028607838, Fidelity 6552642526, GT Bank 0258732080, Stanbic 0021280495
  15. Igwe Ka Ala Enterprises 3750733 Access 1872085373, 0800331795. Fairmoney 2683102063. Fidelity 5090919707, GTB 0206153527, 0044247093, 0044247086, 0044247079, 0044247062, 0044247055, 0044247103, 4020644423. Opay 9023765613, 8035144914, 8126308128. Polaris 3124277058. Carbon 0629821223. Zenith 1226773554
  16. Seficuvi Global Company 3225098 Access Bank 1436852548, Eco Bank 3831141439
  17. Lakurawa Group NLLKW

 


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