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Professor Okogun Calls for Review Process to Boost Homegrown Drug Production

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Stakeholders at every level of intervention have been advised to collaborate and review administrative processes and the approach leading to the identification of plants, scientific research, development and approval of remedies and drug production from Nigerian herbs and plants.

 

This call was made by Emeritus Prof. Joseph Okogun, professor emeritus at the Department of Chemistry, University of Ibadan at a Public Lecture as part of activities to mark his 80th birthday by Bevekt Gedu Chemical Company.

 

The lecture was titled, Active, Bitter and Sweet – A lifetime of Research on Plants, Anti-Cancer Remedies and Drug Discovery.

 

In it, Prof. Okogun discussed plants as unrivaled organic chemical factories producing useful chemicals that man exploits for various purposes, and the reasons why the natural chemistry of plants is important to healthy living. He also spoke on a variety of active ingredients that have been discovered from everyday leaves and fruits found in Nigeria and West Africa that can either treat or manage a lot of common ailments in Nigeria and elsewhere at affordable cost.

 

“There are organic and natural remedies for the management of various diseases including cancer and HIV/AIDS using several decades of data from scientific research on plants by Bevekt Gedu. Out of Bevekt Gedu’s work a pure compound initially obtained from a Nigerian plant which has been adopted and about to be finalized for drug development as a blockbuster drug by IMI of USA. This is an indication that opportunities for long lasting and sustainable investments are abundant locally” sais Prof. Okogun.

 

The event was chaired by Engr. Adama Okoene, former MD Midwestern Oil. It was attended by healthcare professionals, academicians and other professionals from public and private sectors.

 

Prof. Okogun further explained the extraction, isolation, analysis and modification of active natural products for potential drug leads or drugs and molecular probes; and the role of different professionals in the process of drug discovery.

 

Plant materials are usually processed and powdered for extraction with solvents of various polarities so that different types of compounds are extracted by the different solvents. The solvents range from gases (carbon dioxide and hydrocarbon) in supercritical fluid states, petroleum ether through ethanol to water. For instance, the removal of solvent, the usually dark brown gum is separated into the component compounds in the mixture using various chromatographic methods with or without bioactivity screening depending on the nature of the targeted compounds.

 

He explained that Biological activity screening is done by pharmacognosists, pharmaceutical chemists, pharmacologists, biochemists and microbiologists to identify potential drugs and other biologically active compounds including pesticides. Toxicologists determine the toxicity including teratogenicity of identified potential drugs.

 

When biologically active compounds are identified, there may need to improve on the activity and or toxicity by modifying the structures using chemistry linked with biology. Identified potential drugs with known mechanism of actions are used as molecular probes in diagnosis and disease research.

 

Generally, drug discovery and production are result of a multi-disciplinary enterprise and require input from most human disciplines of study which Prof. Okogun gave as follows; botanists as taxonomists, chemists for isolation and chemistry/identification of active principles, zoologists and Animal breeders produce animals needed in in vitro and in vivo studies; while biochemists, pharmacognosist, pharmacologists and microbiologists conduct biological activity studies.

 

In addition, toxicologists do toxicity studies, clinician (human and veterinary) and pharmacist will do clinical studies and use-as medicines, while lawyers and entrepreneurs for patenting and marketing respectively.

 

All of these activities by different stakeholders will create a local value chain and lead to the multiplier effect of saving foreign exchange and thousands of jobs in the rural and urban areas.

 


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Dangote Refinery Denies Liquidity Challenges, Dismisses NNPCL’s $1Bn Loan Claim

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Dangote Petroleum Refinery and Petrochemicals (DPRP) has dismissed claims that the Nigerian National Petroleum Company Limited (NNPCL) used a $1 billion loan secured through a crude forward sale agreement to support the refinery during a liquidity crisis.

Dangote Refinery Denies Liquidity Challenges, Dismisses NNPCL’s $1Bn Loan Claim

In a statement on Wednesday, Anthony Chiejina, company’s chief branding and communications officer, said the NNPCL’s stance was a distortion of the facts.

“We would like to clarify that this is a misrepresentation of the situation as $1bn is just about 5% of the investment that went into building the Dangote Refinery,” Chiejina said.

Chiejina stated that the refinery’s decision to enter into a partnership with the NNPCL was based on the recognition of “their strategic position in the industry as the largest offtaker of Nigerian crude” and at the time, the sole supplier of petrol into Nigeria.

“We agreed on the sale of a 20% stake at a value of $2.76 billion. Of this, we agreed that they will only pay $1 billion while the balance will be recovered over a period of 5 years through deductions on crude oil that they supply to us and from dividends due to them,” Chiejina said.

“If we were struggling with liquidity challenges we wouldn’t have given them such generous payment terms. As at 2021 when the agreement was signed, the refinery was at the pre-commission stage.”

According to the statement, the agreement would have been cash-based rather than credit-driven if the refinery struggled with liquidity issues.

The refinery’s spokesman said the NNPCL was subsequently unable to supply the agreed 300,000 barrels a day of crude (bpd).

He stated that the shortfall was because the NNPPC “had committed a greater part of their crude cargoes to financiers with the expectation of higher production which they were unable to achieve”.

“We subsequently gave them a 12-month period for them to pay cash for the balance of their equity given their inability to supply the agreed crude oil volume,” he said.

“NNPCL failed to meet this deadline which expired on June 30th 2024. As a result, their equity share was revised down to 7.24%. These events have been widely reported by both parties,” he said.


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9mobile Addresses Recent Service Outages, Apologizes for Inconvenience

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9mobile has apologized for the recent service outages experienced by its valued customers which has affected their ability to provide voice, data, internet services. “We understand the frustration these disruptions have caused and deeply regret the inconvenience.

“Our technical team has identified the root causes of the outages including a fire incident at our Main Data Centre in Lagos last night which severely impacted services especially in the Lagos and South-West.  We are grateful for the swift intervention of the Lagos State Fire Service, which helped prevent further damage.

“Prior to the fire incident, our network experienced major fibre interruptions leading to varying degrees of outages. We had a fibre cut on the backbone links in Lagos which led to a total data outage across the country.

“This was followed closely by two vandalism incidents in Lagos and Abuja, leading to total service outage in South-West and data service outage in the North.  Services have now been fully restored in the North & South-South States while restorations work is ongoing in others. We expect to fully restore services as soon as possible”

At 9mobile, customer satisfaction is remains top priority. “We value the trust you place in us and appreciate your patience and understanding during this challenging time. Customers who continue to experience issues can reach out to our customer service team via our social media touchpoints or our experience centres”.

Once again, we sincerely apologize for the disruption and thank you for your continued support.


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NAF Delegation Visits Zinox Technologies, Discuss Partnership

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A high-level delegation from the Nigerian Air Force (NAF) recently visited Zinox Technologies, Africa’s foremost integrated ICT solutions company, exploring avenues for a strategic partnership to strengthen the Air Force’s operational and technological infrastructure.

The delegation, led by AVM SK Usman, Chief of Communications Information Systems (CCIS), included notable figures such as Dr. Asogbon, Strategic Consultant on Communication, Air Commodore Isah, Commander of the 041 CIS Dep, Air Commodore AI Hanidu, Director of Information Technology, Air Commodore HC Usman, Director of Electronic Warfare, Squadron Leader Bilawu, and Group Captain Oloretore, Commander of the 641 CIS Group.

During the visit, NAF representatives commended Zinox Technologies for its significant contributions to technological development across Nigeria and Africa. They emphasized the importance of collaboration in addressing critical needs, including the localization and implementation of robust data storage solutions at NAF headquarters and nationwide offices to ensure data security and accessibility, as well as deploying intelligent and advanced video surveillance systems to enhance security and operational efficiency.

Additionally, the discussions highlighted providing reliable and efficient alternative power solutions to support critical operations and establishing and equipping annex facilities to meet the NAF’s growing data storage and processing requirements. Both parties also proposed solutions to support the development of various data centres for the Air Force. These discussions underscored Zinox’s capability to meet NAF’s complex requirements, leveraging its experience and innovative technology offerings to enhance national security operations.

Zinox Technologies, known for its pioneering role in the African tech industry, has a proven track record and a rich history of impactful projects across Nigeria and the continent. The company has been instrumental in driving digital transformation initiatives, providing cutting-edge IT solutions, and supporting numerous sectors with innovative tech products.

The foremost tech company has executed several transformative initiatives, including Africa’s largest ICT voter registration rollout and impactful e-education and e-health projects in Nigeria. Zinox holds prestigious certifications such as the Microsoft Windows Hardware Quality Lab Certification and ISO 9001:2000.

Zinox’s commitment to technological advancement has earned them a reputation as a leader in the African tech ecosystem, making them a trusted partner for the NAF’s ambitious projects.

By partnering with Zinox, the NAF aims to leverage indigenous cutting-edge technology to enhance its operational capabilities and contribute to the overall development of the Nigerian Air Force. This collaboration highlights Zinox’s unwavering commitment to leveraging technology to support Nigeria’s growth and development.

 


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